Stochastic spreading of intracellular Ca(2+) release.
نویسندگان
چکیده
We study the spreading of calcium-induced calcium release with the stochastic DeYoung-Keizer-model of the inositol 1,4,5-trisphosphate receptor channel. The model shows a transition from isolated release events to steadily propagating waves with increasing IP3 concentration. A state--stochastic backfiring--was found in the regime of steady propagation. The model can be reduced by an adiabatic elimination of the partial differential equation for the Ca(2+) concentration to a lattice of stochastic channel clusters.
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ورودعنوان ژورنال:
- Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics
دوره 62 2 Pt B شماره
صفحات -
تاریخ انتشار 2000